Cognitive inhibition impairments in presymptomatic C9orf72 carriers

Network degeneration and dysfunction in presymptomatic C9ORF72 expansion carriers

Hexanucleotide repeat expansions in C9ORF72 are the most common known genetic cause of familial and sporadic frontotemporal dementia and amyotrophic lateral sclerosis. Previous work has shown that patients with behavioral variant frontotemporal dementia due to C9ORF72 show salience and sensorimotor network disruptions comparable to those seen in sporadic behavioral variant frontotemporal dement...

Early cognitive, structural and microstructural changes in c9orf72 presymptomatic carriers before 40 years of age

350 words) Importance: Presymptomatic carriers of c9orf72 mutation, the most frequent genetic cause of FLTD and ALS, represent the optimal target population for the development of diseasemodifying drugs. Preclinical biomarkers are needed in order to monitor the effect of therapeutic interventions in this population. Objectives: To assess the occurrence of cognitive, structural and microstructur...

Presymptomatic signs in healthy CJD mutation carriers.

Creutzfeldt-Jacob disease (CJD) is a rapidly progressing dementia with neurological, psychiatric and cognitive symptoms. We focused our study on the familial CJD form among Libyan Jews (the E200K mutation), trying to identify preclinical neuropsychological signs in mutation carriers to facilitate early diagnosis of the disease. A wide range of neuropsychological tests was administered to 27 hea...

Are Presymptomatic Carriers of Huntington’s Chorea

Radiation- induced cognitive impairments

Introduction: Ionizing radiation is non-surgical treatment of brain tumors and metastases. Preclinical studies have showed main insights into harmful effects of radiation on the nervous system in vivo and in vitro. Cognitive impairment such as progressive memory, executive and attention performance deficits indicates a significant risk for patients experiencing conventional rad...